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For labs studying the full spectrum of incretin biology and energy homeostasis, Retatrutide 40mg is not just the better option its the only option that covers all three pathways in one compound, at a volume suited to serious research programmes
Unfortunately, like other GLP1R agonists, retatrutide also produced significant GI side effects in a large proportion of participants (35% in the 36 week study and 45% in the 48 week study at the 12 mg dose) (Rosenstock et al., 2023)
As IGF-1R mAbs are already in clinical trials, these observations warrant further exploration into the possible development of these drugs for safe and effective long-term use in humans as a strategy to delay at least some manifestations of aging
Both medications are weekly injections that work on the hormones tied to hunger, metabolism, and blood sugar
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